Medical Paper:

Liuweiwuling tablets attenuate BDL-induced hepatic fibrosis via modulation of TGF-β/Smad and NF-κB signaling pathways

Generic name: Liuwei Wuling tablets
Chinese Pinyin: liuweiwulingPian
Product name: Expo
Ingredients: Schisandra, Ligustrum lucidum, Forsythia, Zedoary Turmeric, Cocory, Ganoderma lucidum spore powder.
Properties: This product is a film-coated tablet, which is brown after removing the film coating; slightly fragrant, slightly bitter taste.
Functions and indications: Nourish the kidneys and liver, promote blood circulation and detoxify. It is used for the treatment of chronic hepatitis B aminotransferase elevation. TCM syndromes belong to liver and kidney deficiency, evil toxins, blood stasis and heat. Symptoms: flank pain, waist and knee weakness, dry mouth and throat, fatigue, fatigue, anorexia, Swelling, yellow or not yellow body and eyes, yellow urine, dizziness, dry eyes, hot hands, feet and heart, insomnia and dreaminess, dark red tongue or ecchymosis, little or no moss, thin pulse.
Specification: 0.5g*36 pieces/box
Usage and dosage: Orally, 3 tablets at a time, 3 times a day, for 3 months; then decrease every month, and then continue for 3 months. In the first month of weight reduction, 3 tablets at a time, 2 times a day; in the second month of weight reduction, 2 tablets at a time, 2 times a day; in the third month of weight reduction, 2 tablets at a time, once a day.
Adverse reactions: In a clinical trial, 1 patient had abnormal electrocardiogram (left anterior branch block, T wave change). Whether it is related to the test drug is still uncertain.
Contraindications: Prohibited by pregnant women.
Note: Avoid tobacco, alcohol and spicy food.
Pharmacology and Toxicology: Animal test results suggest that Liuwei Wuling Tablets can inhibit the increase in serum transaminase, the decrease of total protein (TP) and albumin (ALB) in rats caused by CCl4, and reduce the content of liver collagen; inhibit D-galactose Elevated serum transaminase in mice caused by amine (D-GalN). It has a protective effect on the immune liver injury induced by BCG and lipopolysaccharide (LPS) in mice; it promotes half of the hemolysin and the phagocytic function of the reticuloendothelial system in mice and the improvement of lymphocyte transformation rate. The alkaline phosphatase (ALP) activity of mice with liver injury caused by paracetamol decreased significantly, and the blood triglyceride (TG) content decreased; the sodium sulfonate (BSP) retention in the liver of mice decreased. It can inhibit the replication and expression of 2.2.15 cell surface antigen (HBsAg) and e antigen (HBeAg); inhibit the increase of duck hepatitis B virus DNA in the serum of ducks infected with duck hepatitis B virus.
Storage: sealed.
Packing: medicinal double aluminum blister pack, 12 pieces per board, 3 boards per box;
Validity period: 24 months
Executive standard: State Food and Drug Administration Standard National Drug Standard YBZ06972006-2009Z
Approval number: National Medicine Standard Z20060238
Company Name: Shandong Shibo Jindu Pharmaceutical Co., Ltd.
Company Address: No. 1 Lanyan Avenue, Zibo Development Zone