Traditional Chinese Medicine. Shenxian Shengmai Oral Liquid or Shenxian Shengmai Koufuye or Shen Xian Sheng Mai Kou Fu Ye or SXSM Oral Liquid or ShenxianShengmai Koufuye or ShenxianShengmaiKoufuye for bradyarrhythmias or slow arrhythmia.

NAMES
Shenxian Shengmai Koufuye
Shenxian Shengmai Oral Liquid
SXSM Oral Liquid
ShenxianShengmai Koufuye
ShenxianShengmaiKoufuye
Shen Xian Sheng Mai Kou Fu Ye
Shen Xian Sheng Mai Oral Liquid
参仙升脉口服液

It has been listed in the Chinese national directory of health insurance in 2017. Animal experiments showed that SXSM can increase heart rate by inhibiting heart parasympathetic transmission based on the decreased CHRNA2 (encodes nicotinic acetylcholine receptor) and increased ACE-1 (encodes acetylcholinesterase). SXSM upregulated ATP2A1 and FKBP1B, therefore, restored Ca2+ stores induced by restored expression of SERCA2a and FKBP12.6 contributed directly to increased heart rate. In addition, in ventricular myocardium, SXSM increased the supply of ATP by enhancing TCA cycle and oxidation-respiratory chain. It also upregulated proteins ranged from enzymes of TCA cycle to subunits of complex I and ATP synthase

For bradyarrhythmias or slow arrhythmia.

INGREDIENTS
red ginseng, epimedium, psoralen, medlar, ephedra, asarum, salvia, and leech

DESCPRIPTION
This product is a brownish red liquid with a small amount of precipitation after long-term storage; The air is faint and the taste is pungent

FUNCTION and INDICATIONS
Warming the heart and kidney, promoting blood circulation and removing blood stasis. This product is used for the syndrome of Yang deficiency and pulse delay. The symptoms include pulse delay, pulse knot, palpitation, chest tightness,Cold phobia, cold limbs, aching knees, shortness of breath, weakness or dizziness, dull tongue or tooth marks, or petechiae and blood stasis on tongue Point. It is equivalent to mild and moderate sinus bradycardia (heart rate > 50 times) and mild sick sinus syndrome Heart kidney yang deficiency and cold coagulation blood vessel syndrome complicated with supraventricular tachyarrhythmia.

SPECIFICATION AND PACKAGE
10ml/bottle, 6 bottles/box.

USAGE AND DOSAGE
Oral, 2 bottles per time, 2 times per day; or follow the doctor's advice.

ADVERSE REACTION
Some patients have dry mouth and stomach discomfort after taking medicine.

TABOO
1. Those with hyperactivity of liver Yang and excessive damp heat are forbidden.
2. This product should not be used for slow fast syndrome in sick sinus syndrome.
3. Use with caution in patients with hypertension.
4. Use with caution for pregnant and lactating women.
5. Use with caution for those with serious heart disease.
6. This product is not recommended for patients with sick sinus syndrome who need pacemakers.

[precautions]
1. Athletes should use it with caution.
2. Please use it under the guidance of a doctor.
3. Pay attention to the changes of heart rate and blood pressure during medication. If it is found that the heart rate does not improve significantly, other treatment measures should be taken. If the blood pressure is too low or too high, corresponding treatment measures should be taken.
4. Avoid eating too much raw or cold.
5. If the patient's condition is found to be aggravated during the treatment, the comprehensive treatment measures of traditional Chinese and Western medicine should be adhered to.

[clinical trial]
this product was approved by the pharmaceutical administration of the Ministry of health of the people's Republic of China in 1992 for 442 clinical trials.

[pharmacology and toxicology]
formaldehyde induced sinus node slowing test in rabbits shows that this product has the effect of increasing heart rate and shortening sinus node conduction time.

STORAGE
Hermetically sealed,keep in cool and dry places.

PERIOD OF VALIDITY
24 months.

CERTIFICATE NO
Stage Food and Drug Administration Approval number:Z20080183.

Manufactured
SHANDONG BUCHANG PHARMACEUTICAL CO.,LTD

TIPS
Please read the directions for use in retail or directed by physician.
Part of the goods frequent replacement of packaging, such as goods and pictures are not exactly the same, please refer to the goods you receive.

General Cautions
Keep away from animals and children.This product has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.We highly recommend that you consult with a Traditional Chinese Medical practitioner or physician before taking any products or if you have any questions regarding your health.